A native of New York City, Romero moved to Mexico in her youth, and later established a career there as an actress.

In 1979 she filmed Cuatro mujeres y un Hombre, Bandera Rota and My Horse Cantador, and also appeared in the telenovela Angel Guerra alongside Andrea Palma and Diana Bracho.

In 1983 Romero returned to Mexico and made film and television appearances as The Castaways of Liguria directed by her then husband Retes.

In 1986 she starred in the film Miracles, and in 1988 returned to Hollywood to take part in Clif Ossmond's movie The Penitent.

In the 1990s and 2000s she participated in such notable telenovelas as; Cadenas de Amargura (1991), Muchachitas (1991), Alondra (1995), Rosalinda (1999, with Thalía), Abrázame muy fuerte (2000), and most recently Pasión (2007), Mi pecado (2009) and Una Maid en Manhattan (2011), among others.