[5] Watkins' mother moved her from Des Moines to Atlanta, when she was nine years old, after living in California and Houston for a short time.

Additionally, she has been a featured vocalist on songs such as "Ghetto Love" with Da Brat, "Changes" with Society of Soul, "He Say She Say" with Keith Sweat, "Different Times" with Raphael Saadiq and "Be Somebody" with Paula Cole.

[10] The song was released digitally, and proceeds went to help raise awareness for people suffering from blood conditions such as sickle cell and leukemia.

[11] On September 6, 2017, Watkins digitally released her latest single titled "Dreams" from her audiobook "A Sick Life".

[15] Watkins made a guest appearance as Pam Grier in one episode of the Adult Swim series Black Dynamite.

[16] Watkins' reality TV show, Totally T-Boz, premiered January 1, 2013, on the TLC network, and ran four episodes.

[6] The show chronicled Watkins' quest to create a solo album, reunite with bandmember, Chilli, and her life with her daughter Chase.

In 2016, Watkins and Chili joined actress Zoe Saldana onstage for her second round performance of "No Scrubs" on Spike's Lip Sync Battle against actor Zachary Quinto.

[19] In 2005, Watkins and stylist Tara Brivic (who would later appear regularly on Totally T-Boz) opened a children's boutique called Chase's Closet (named after her daughter).

[23] TLC celebrated their return with a series of highly publicized performances which included 2 dates: VH1's Mixtape Festival in Hershey, Pennsylvania, on July 27, 2013, and Drake's OVO Fest in Toronto on August 5, 2013.

[32] In 2012, Watkins moved with the couple's daughter from Atlanta to Los Angeles, California, in order for Chase to be closer to her father.

[33][34] In March 2006, she was diagnosed as having a grape-sized acoustic neuroma on her vestibular nerve that affected her balance, weight, hearing, sight, and facial movement.