Tirfi Tsegaye Beyene (born 25 November 1984) is an Ethiopian long-distance runner who competes in marathon races.

Born in Bekoji in Ethiopia's Oromia Region, she comes from a town renowned for producing world class runners such as Kenenisa Bekele and Tirunesh Dibaba.

[14] She was the pre-race favourite for the Paris Marathon and delivered on the status by winning the race in a course record and personal best time of 2:21:39 hours, over three minutes ahead of runner-up Sultan Haydar.

[15] Running alongside her training partner, Aberu Kebede, she was runner-up at the 2012 Berlin Marathon with a personal best time of 2:21:19 hours.

[16] In January 2013, she won the Dubai Marathon despite the heavy fog during the race, with a time of 2:23:23, 16 seconds ahead of runner-up Ehitu Kiros.