The southern part of the Titipiti River Valley is served by route 212 which connects Obedjiwan to La Tuque and passes south of Lake Dubois.

The surface of the Titipiti River is usually frozen from early November to mid-May, however, safe ice movement is generally from mid-November to mid-April.

The Titipiti River originates at the mouth of a Valcourt Lake (length: 0.8 kilometres (0.50 mi), altitude: 447 metres (1,467 ft)) in the Township of Ventadour, in Lac-Ashuapmushuan, Quebec (unorganized territory).

The confluence of the Titipiti River with the Feuquières Lake is located at: At various times in history, this territory has been occupied by the Attikameks, the Algonquin and the Cree.

The toponym "Titipiti River" was officialized on December 5, 1968, at the Commission de toponymie du Québec, when it was created.