The first recorded bishop of Tarsus, Helenus, went to Antioch several times in connection with the dispute concerning Paul of Samosata.
Tarsus was the metropolitan see of the province of Cilicia Prima, under the Patriarchate of Antioch.
[2] From the 6th century onwards, the metropolitan see of Tarsus had seven suffragan bishoprics (Échos d'Orient, X, 145).
Tarsus is included in the Catholic Church's list of titular sees as a metropolitan see of both the Latin, the Maronite and the Melkite Catholic Church.
[4] The Church of the East had a diocese of Tarsus that was a suffragan of Damascus, but no incumbents are known by name.