The U.S. Government developed the airport to serve as an outlying field (OLF) to Naval Air Station Sanford during World War II.

Having previously used military facilities on nearby Cape Canaveral Air Force Station, the National Aeronautics and Space Administration (NASA) began development of its own civilian staffed launch facilities, in what became the John F. Kennedy Space Center (KSC), on Merritt Island in the early 1960s.

Eastern Air Lines Boeing 727 and McDonnell Douglas DC-9 jetliners served Titusville with scheduled passenger flights from 1970 to 1974.

The 1963 Act established policies for the funding of Authority activities, including an ad valorem tax not to exceed one mil on all taxable properties within the geographical bounds of the District.

[2] Space Coast Regional Airport covers 1,650 acres (668 ha) and has two runways: The Valiant Air Command is a frequently flyable collection of planes used in World Wars I and II.

[4] The museum provides an exhibit of air history, offering a static display of vintage Warbird aircraft, including a Douglas C-47A.

[6] The Zero Gravity Corporation offers weightless flights in its modified Boeing 727 and Airbus A300 cargo planes.