Titusville Area High School was originally constructed[2] in 1931.

Subsequent additions took place in 1941, 1957, and 1965, at which time the junior high wing was added.

More additions, along with a major renovation took place in 1979, at which time a 25-meter swimming pool was added.

The junior high students moved from the school to a sole middle school building in 1999, after which, a major renovation took place to the entire structure including improvements for energy-efficiency and student safety.

Titusville High School has an active alumni association that was organized in 1996 and has an endowed scholarship fund that exceeds one million dollars.