[16] In November 2003, Ferro released his second studio album, 111, recorded both in Italian and Spanish, produced by Alberto Salerno, Mara Maionchi and Michele Canova.

[24] In July 2004, Ferro also released in Europe his first English-language single, "Universal Prayer", a duet with British R&B singer Jamelia recorded to promote the 2004 Olympic Games in Athens, Greece.

[29] The album, described by music critics as more intimate and melancholic,[30] obtained in Italy a success even bigger than his previous ones, reaching diamond certification by FIMI for its domestic sales.

[31][32] The third single from the album, "Ti scatterò una foto", was included in the soundtrack of the movie Ho voglia di te, directed by Luis Prieto and based on the book with the same title by Federico Moccia.

[33] Nessuno è solo also features a duet with Italian pop singer-songwriter Biagio Antonacci,[34] while the Spanish-language version of the album includes "Mi credo", a song recorded with Pepe Aguilar.

[35] In June 2008 Ferro co-wrote with Roberto Casalino the single "Non ti scordar mai di me" for X Factor Italy's first edition's runner-up Giusy Ferreri.

[39] On 7 November 2008 Ferro released his fourth studio album, Alla mia età / A mi edad, preceded by the single with the same title.

[43] The album contains a duet with singer-songwriter Franco Battiato, and "Breathe Gentle", the English version of third single "Indietro", features Kelly Rowland.

Other collaborators to the project included Italian songstress Laura Pausini, Anahí and Dulce María of Mexican pop group RBD and Amaia Montero.

In November 2009, Ferro released his first video album, Alla mia età – Live in Rome, recorded during his concerts at the Stadio Olimpico on 24 and 25 June 2009.

[50] During the spring and summer of 2012, Ferro embarked on a largely domestic concert tour, with additional stops in Switzerland, Belgium and Monaco.

Italian female hip hop artist Baby K released her debut album Una seria in March, which was produced by Ferro together with Michele Canova.

[69] Ferro opened the Sanremo Music Festival 2017 by singing "Mi sono innamorato di te" as a tribute to Luigi Tenco, marking the 50th anniversary of his death.

[73] In 2018, Ferro collaborated with Ed Sheeran and his brother Matthew on the composition of "Amo soltanto te"[74] ("This Is the Only Time" in the English version).

[77][78][79] Accetto Miracoli contains 12 tracks: "Vai ad Amarti", "Amici per errore", "Balla per Me" (a duet with Jovanotti), "In mezzo a questo inverno", "Come farebbe un uomo", "Seconda pelle", "Il destino di chi visse per amare", "Le 3 parole sono 2", "Casa a Natale", "Un Uomo Pop", "Buona (Cattiva) Sorte" and "Accetto Miracoli".

Only in digital formats, there are 2 additional bonus tracks, "Accetto Miracoli" and "In mezzo a questo inverno", arranged by the producer Julio Reyes Copello.

[citation needed] An Italian tour for Accetto miracoli was originally scheduled for 2020, but was postponed to 2021 due to the COVID-19 pandemic in Italy, and later canceled.

[85] Ferro's newest album, Il mondo è nostro, was released on 11 November 2022, with an Italian stadium tour set for summer 2023.

[89][90] Ferro's album also includes duets with Sting ("For Her Love"), Roberto Vecchioni ("I miti"), Caparezza ("L'angelo degli altri e di se stesso") and Ambra Angiolini ("Ambra/Tiziano").

[92] Ferro subsequently released multiple post-album singles in 2023: "Destinazione Mare";[93][94] a new version of "Vamos a bailar" with Paola and Chiara;[95] and "Abbiamo vinto già" with J-Ax.

[99][100] In February 2025, Massimo Ranieri performed the song "Tra le mani un cuore [it]", written by Ferro with Filippo Neviani, Giulia Anania [it], and Marta Venturini, at the Sanremo Music Festival 2025.

[103][104][105] It tells the story of Angelo Galassi, a former Italian pop star living in obscurity in New York, who must face his personal issues and pull himself together for the sake of his newly-discovered young daughter.

[106] In September 2023, Ferro canceled the Italian promotional tour for the novel, explaining that his pending divorce prevented him from leaving his home in Los Angeles with his children.

[112] In early 2010 his desperation led him to break down and came out to his father, an event that inspired the title of his first book, Trent'anni e una chiacchierata con papà (Thirty years old and a chat with dad).

[125] Ferro has spoken out against what he refers to as Italy's anti-homosexual policies, in particular the many obstacles to parenthood for homosexual couples, including the criminalization of surrogacy and the government's refusal to recognize a second same-sex parent.

[84][121][126] Many of Ferro's songs have been used in films and television series, including "Sere nere" in Three Steps Over Heaven (Tre metri sopra il cielo) (2004); "Ti scatterò una foto" and "La paura che..." in Ho voglia di te (2007); "L'amore è una cosa semplice" and "TVM" in Love Is Not Perfect (L'amore è imperfetto) (2012); and "La differenza tra me e te" in All Roads Lead to Rome (2015).