Tiznow's unraced full sister Tizamazing produced 2013 Preakness Stakes winner Oxbow, by the stallion Awesome Again.

When Straub-Rubens died shortly after the 2000 Breeders' Cup Classic,[4] Tiznow's ownership was changed to Cee's Stable.

Especially towards the end of his career, he was sometimes reluctant to work in the mornings, including one occasion before the 2001 Breeders' Cup where he spent 40 minutes resisting jockey Chris McCarron's urging to break into a gallop.

[10] In the Pacific Classic, Tiznow faced older horses for the first time and finished second when Skimming got an early lead and kicked clear of the field.

[11] This was the first time he was ridden by jockey Chris McCarron, who quickly learned that Tiznow disliked the whip and adjusted tactics accordingly.

He won in gate to wire fashion by six lengths under a hand ride, breaking the track record for 1+1⁄8 miles.

[13] Returning to California for the Goodwood Breeders' Cup Handicap, Tiznow grabbed the early lead and then withstood a challenge down the stretch from Captain Steve to win by 1⁄2 a length.

[18] At high weight in the Santa Anita Handicap, Tiznow dueled with Wooden Phone for a mile before drawing away to win by 5 lengths.

[19] Tiznow then missed a good portion of the year due to back problems and came into the Classic off defeats in the Woodward Stakes and the Goodwood Handicap.

It was six weeks and four days after the terrorist attacks that took place just miles to the west in Lower Manhattan, but the 2001 Breeders' Cup went ahead as planned, with armed marksmen lining the rooftop at Belmont Park.

[20] The American runners were led by Aptitude, winner of three straight races including the Jockey Club Gold Cup.

Retired to stud at WinStar Farm, Tiznow was considered an uncertain stallion prospect due to his relatively modest California breeding.

[23] His pedigree is unusual for a great horse; he is one of the few modern Thoroughbreds whose sire line does not end at the Darley Arabian.

After Straub-Rubens death, Cee’s Song was purchased carrying Tizamazing for $2.6 million at the 2001 Keeneland November breeding stock sale.

Relocated to Kentucky, Cee’s Song produced four more offspring including stakes-placed C’Mon Tiger, by Storm Cat, and his winning full sister You’re Beautiful.