Tlapa de Comonfort, often shortened to Tlapa and known as Tindaꞌi in Mixtec, is a city in the mountain region of the Mexican state of Guerrero.

"Tlapa" is a Nahuatl exonym from tlappan or tluhpan, meaning "place of washing".

References to it also exist in codices and wood carvings from the town of Chiepetlán, claiming it was founded in 1607, and in the Humboldt Codex.

The municipality was founded in 1912, with the excision of Guerrero from the states of Puebla and México.

The 2005 INEGI Census reported a population of 37,975 in the municipal seat.