Edwards began his career producing primarily for New York's Nervous Records in the 1990s, including under aliases such as the Messenger and the Sample Choir.

Edwards has remixed hundreds of artists, including Wildchild, St Germain, Benjamin Diamond, Justice, Klaxons and Dimitri from Paris.

[2] In 1995, his manager was approached by French producer St Germain, who requested Edwards to remix his song "Alabama Blues."

[9] After deciding to return to music, Edwards sent an email to Thomas Bangalter of Daft Punk to congratulate him and Guy-Manuel de Homem-Christo on their 2010 album Tron: Legacy.

"[14] In April 2020, London-based house label Defected Records announced that they had acquired Edwards' catalogue, most of which had previously been available exclusively on physical mediums such as vinyl and CDs.

[15][16] In May 2021, Edwards and Defected Records announced that his back catalogue would be available digitally for the first time, with remastered releases, remixes, and previously unreleased songs.

[18] On March 22, 2023, a bonus track from the 10th anniversary edition of Random Access Memories titled "The Writing of Fragments of Time" was released.

[19] The single is an eight-minute track consisting of multiple spoken discussions and sung improvisations between Thomas Bangalter and Todd Edwards as they work on the lyrics and melody of the song.

[21] Edwards's style of music production features four-on-the-floor swing beats and is characterized by vocal samples cut into tiny fragments and reassembled.

In separate interviews about his favorite tracks, he included songs by Roy Davis Jr., TJR, Armand van Helden, and other artists from the US and UK garage scenes.

Ben Cardew described Edwards's technique as a refinement of MK's style, calling it a "buoyantly rhythmic and geometrically patterned mosaic," which served as an inspiration for Daft Punk.

His faith is subtly reflected in his music, as many of his compositions include hidden messages and vocal samples containing religious phrases, often layered within his signature production style.