Gurley immediately made an impact in his first season by rushing for over 1,000 yards and winning Offensive Rookie of the Year.

As a senior in 2011, he was the North Carolina Associated Press (AP) Player of the Year after totaling 2,600 yards and 38 touchdowns.

He competed for Team USA in the 110-metres hurdles at the 2011 World Youth Championships in Athletics, where he placed 3rd in the prelims with a career-best time of 13.66 seconds,[7] but finished 15th overall in the semifinals.

[8] Also a top competitor in the 100-meter dash, he ran a personal-best time of 10.70 seconds in the prelims of the 2011 NCHSAA 2A State Track Meet, placing 2nd.

[14] Gurley took over as the starter the second game of the season against Southeastern Conference (SEC) East opponent Missouri and rushed for 65 yards on 10 carries in the 41–20 victory.

Even though the Bulldogs lost the game 38–35, Gurley had an impressive performance against Clemson which included a 75-yard touchdown run early in the first quarter.

He competed in the 60-meter hurdles, and recorded the seventh-fastest time in school history at 8.12 seconds, to take sixth place at the VT Elite Meet.

[42] His 208 rushing yards were the most in a single game by a Georgia running back since Garrison Hearst had 246 against Vanderbilt in 1992.

[26] On October 9, Gurley was indefinitely suspended by the University of Georgia over an alleged violation of NCAA rules.

[45] In his first game back from suspension on November 15, Gurley tore his ACL against Auburn, ending his junior season and his career at the University of Georgia.

[53] Gurley's rehabilitation went ahead of schedule and during the team's preseason, while he did not play, he practiced without wearing pads.

[55] The following week, the Rams visited the undefeated Arizona Cardinals for an NFC West divisional matchup.

[60] Following the 27–6 win over the 49ers in Week 8, Gurley's jersey and cleats were inducted into the Pro Football Hall of Fame.

[61] In Week 9, Gurley was held to 89 yards on 24 carries in the Rams' 21–18 overtime loss to the Minnesota Vikings.

[63] In Week 11, Gurley rushed for 66 yards on 25 carries against the Baltimore Ravens and scored a touchdown in a 16–13 loss.

[65] The following week, he was held to 41 rushing yards on nine carries in a 27–3 loss at home in the second divisional matchup against the Arizona Cardinals.

[68][69] Gurley finished his rookie year with 1,106 rushing yards and ten touchdowns on 229 attempts despite making only 12 starts (he sat out the Rams' season-ending loss at San Francisco).

[70] On December 22, 2015, Gurley was selected to be part of the 2016 Pro Bowl along with fellow Rams players defensive lineman Aaron Donald and punter Johnny Hekker.

[72] Gurley was one of the five rookies to be selected to the Pro Bowl, along with Kansas City Chiefs cornerback Marcus Peters, Seattle Seahawks wide receiver/kick returner Tyler Lockett, Oakland Raiders wide receiver Amari Cooper, and Tampa Bay Buccaneers quarterback Jameis Winston.

[81][82] Following the firing of Jeff Fisher and subsequent hiring of Sean McVay as new head coach, Gurley looked to rebound off of a down year which frustrated him with the Rams, prompting him to call the former playbook of the team similar to that of a "middle school offense".

[94] In Week 15, Gurley had a career-best four touchdowns (three rushing, including a 57-yarder on 3rd and 20 with 30 seconds left in the first half) on 180 yards from scrimmage in a dominant 42–7 win over Seattle.

[102] The playoff-bound Rams decided to have Gurley sit out the last game of the season against the San Francisco 49ers, allowing Kareem Hunt to win the title for rushing yards, but he still led the NFL with 13 rushing touchdowns, 19 total touchdowns, and 2,093 yards-from-scrimmage and all-purpose yards.

[105] Gurley played his first career post-season game in the Wild Card Round against the Atlanta Falcons on January 6, 2018.

[111] Gurley scored the Rams' first touchdown of the season, taking a short pass from quarterback Jared Goff and going 19 yards to the end zone against the Raiders in Week 1.

[113] In Week 2, in the 34–0 victory over the Cardinals, Gurley recorded three rushing touchdowns for the second time in his professional career.

[120] During a Week 12 matchup against the Lions, Gurley rushed for 132 yards and two touchdowns in the fourth quarter to help the Rams clinch their second straight NFC West title and was named NFC Offensive Player of the Week for the second time in 2018.

[127] In the NFC Divisional Playoff against Cowboys, Gurley ran 16 times for 115 yards and a touchdown in the Rams' 30–22 victory.

However, he scored a touchdown with 1:04 remaining to give the Lions a chance to get the football back and win the game, which they did.

[149] On May 23, 2022, Gurley joined the ownership group for the FCF Beasts of the Fan Controlled Football League.

The initiative was collaborating with nonprofit organization First Book to fulfill the company's goal of providing access to a quality education for needy children.