[1] He traveled extensively during his long life and had important friendships with artists such as Berenice Abbott, Walker Evans, Alfred Stieglitz, Georgia O'Keeffe, Ansel Adams, Dorothea Lange,[2] and Harry Callahan.

[1] From 1924 to 1929 he worked as a bank teller and clerk at a brokerage firm in Detroit; in another account, he was a successful stockbroker during the 1920s but lost his earnings during the Crash before the Depression.

[1] In 1941, he visited Rocky Mountain State Park with Harry Callahan, and realized during this trip that he was drawn more to the urban cityscape, and although he found Adams to be an inspiration, he would not make photographs like his teacher.

[1] He made key friendships with Alfred Stieglitz and Georgia O'Keeffe as well as Beaumont Newhall, Berenice Abbott, Helen Levitt, and Minor White.

[3] Webb began a remarkable project of walking the streets of New York City with his heavy camera and tripod and photographing people and buildings he encountered.

[4] One large 10-foot–long panorama photograph which was critically acclaimed[5] showed a section of Sixth Avenue from 43rd–44th streets which, in 1991, was seen as a "visual time capsule of the city" and was described as a "stunner.

1950) shows a grim industrial view towards Pittsburgh from a hill near Westinghouse Bridge that takes in a bare river valley across which snake highways and railways and a row of tall smokestacks in the distance.

[9][10] Curator Edward Steichen selected it for the 1955 Museum of Modern Art exhibition The Family of Man, seen by 9 million visitors on its world tour.

These rich color images were published in 2021 as a book to complement the exhibition at the Minneapolis Institute of Art titled Todd Webb in Africa, Outside the Frame.

[16] Webb's landscape photographs as well as photos of the artist walking among the sagebrush bring O'Keeffe to life "even in pictures where she doesn't appear", according to Chicago Tribune art critic Abigail Foerstner.

In 2006, the Hallmark Greeting Cards Corporation acquired at least 161 of Webb's photographs, and in 2006 decided to give them away in a generous donation to the Nelson-Atkins Museum in Kansas City.