All games are played at Meiji Jingu Stadium in Kasumigaoka, Shinjuku in downtown Tokyo.

Games are known to be rowdy and celebratory, with cheerleading squads (応援団, Ōendan) and bands working themselves and the crowd into a frenzy.

The league was suspended in 1943 due to World War II, but immediately after the end of the war, on October 28, 1945, a six-college alumni game was held, culminating in a game between Waseda and Keio University at Meiji Jingu on November 18.

[1] On April 1, 2013, the league registered as a general incorporated foundation, the Tokyo Six Universities Baseball Federation.

[1] According to the league's website, 119 players and executives associated with Tokyo Big6 have been inducted into the Japanese Baseball Hall of Fame.

Current as of Autumn 2023 The series between Waseda and Keio, Sōkeisen (早慶戦[4]), attracts the most attention and is greatly enjoyed by the students, not least because it causes classes at both universities to be canceled.

Sō, is the alternate reading of Wa (早) in Waseda (早稲田) (also from the short name, Sōdai (早大)), while Kei (慶) is the first character of Keio (慶応).