He was tied with teammate Nick Jensen for the league lead with a plus-30 rating despite being limited to 55 games due to injury.

In six games for the Red Wings, he registered two penalty minutes, six hits and three takeaways while averaging 10:08 time on ice during his first NHL call-up.

Nosek appeared in 11 games for the Red Wings, and recorded his first career NHL goal on 28 March against Cam Ward of the Carolina Hurricanes.

[9] On 10 October 2017, Nosek scored the Knights' first franchise goal on home ice at the T-Mobile Arena.

[11] As a restricted free agent, Nosek signed a one-year, $962,500 contract with the Golden Knights on 18 July.

[13] After four years as an original member of the Golden Knights, Nosek left as a free agent following the 2020–21 season.

Nosek as a free agent signed a one-year, $775,000 deal with the Florida Panthers on July 1, 2024.

[18] Nosek represented the Czech Republic at the 2012 World Junior Ice Hockey Championships, where he served as team captain and recorded one assist in six games.