After settling in New Mexico as governor, he noticed the frequent attacks the Comanches were directing against the places where the Spanish and Mestizos lived.

These attacks were not only dangerous because they resulted in kidnappings and the killing of settlers and their descendants in the province, they also impeded economic growth.

To remedy this situation, Vélez Cachupin decided to improve the quality of life of the indigenous people, hoping that they would respect him.

They were distributed in forty tents and established commercial relations with the residents of the region, with who they exchanged hides and slaves.

Vélez Cachupin forced them to refrain from attacking Spanish settlements, warning them that if they did, he would ban their trade with Taos and he would murder all of them.

In fact, Vélez wrote to his successor about the behavior and the actions he should take when he contacted with Comanches, in order to no misunderstandings and maintain peace in New Mexico.

These last ones were founded in strategic places, creating: Abiquiu, Las Trampas, Ojo Caliente and Truchas among others.

The Franciscans tried to expel Cachupin from his position as governor, but were unable to do so, probably due to the familiarity and friendship that had between Cachupín and Viceroy Revilla Gigedo.

This was because the French had started a trade war with New Mexico and were trying to occupy most of northern Spanish Texas, making France one of its main rivals.

[3] The expedition traveled through southwestern Colorado and southeastern Utah (which belonged to Spain at this time), establishing sections of future Old Spanish Trail.

He also banned inhabitants from El Paso–Juárez (which at that time was a unique city) from entering Amerindian lands for any reason including grazing sheep, or gathering firewood.

[5] In November 1765, Cachupín was forced to ban tobacco growing in New Mexico, following a law issued by the Viceroy, who had established a monopoly on the plant.

However, the governor had tried unsuccessfully to prevent enforcement of the law, because it could harm the economy of the province and the relations between the Native Americans and the Spaniards, since they bought the tobacco from the farmers of New Mexico.

[1] He was replaced by Francisco Antonio Marín del Valle as governor of Santa Fe de Nuevo México province in 1767.