His film work includes a starring role as drummer Guy Patterson in the film That Thing You Do!, the protagonist in An American Werewolf in Paris, and notable roles in Boiler Room, One True Thing, Dead Man on Campus, The Love Letter, Because I Said So, Danger One, La La Land, and Clouds.

[5] After appearing in an episode of Law & Order and a commercial for Crest toothpaste in 1993, Scott's first notable role was as Matthew for several seasons on the television situation comedy Grace Under Fire.

[6] Scott has had several other roles; he was the lead in the films An American Werewolf in Paris and Dead Man on Campus, and co-starred with Kate Capshaw and Tom Selleck in The Love Letter.

Scott had supporting roles in other films such as Race to Witch Mountain, Tanner Hall, Mars Needs Moms, Parental Guidance, Enemies Closer, Sister Cities, and portrayed an affable but amoral paramedic in Danger One.

His former television roles include Sam Landon in Beauty and the Beast, Kevin Duval in Scream, Charles Garnett in Z Nation, and William in Reign.

In 2017, he co-starred in the film Diary of a Wimpy Kid: The Long Haul, and was a series regular on the TruTV sitcom I'm Sorry, starring alongside Andrea Savage for two seasons.