In each of his last two seasons with the Medicine Hat Tigers, Lysiak was awarded the Bob Clarke Trophy as the Western Canadian Hockey League's leading scorer, with a total of 297 points in 135 games.

Lysiak joined the Flames for the 1973–74 NHL season, the second year for the franchise, and scored a team-high 64 points.

He helped the team to its first playoff berth and finished second in the voting for the Calder Memorial Trophy (top rookie).

Lysiak played seven full seasons for Chicago and in 1980–81 led the team in scoring with 76 points, including a career-high 55 assists.

On October 30, 1983, while a member of the Black Hawks, Lysiak tripped linesman Ron Foyt during a game against the Hartford Whalers.