[1] LiPuma worked with many musicians, including Barbra Streisand, Miles Davis, Bill Evans, George Benson, Phil Upchurch, Al Jarreau, Anita Baker, Natalie Cole, Gábor Szabó, Claudine Longet, Dave Mason, the Yellowjackets, the Sandpipers, Michael Franks, Diana Krall, Paul McCartney, Ben Sidran, The Crusaders, Joe Sample, Randy Crawford and Dr. John.

Inspired by the cultural changes of the late 1960s, including such events as the Monterey Pop Festival, LiPuma formed the Blue Thumb label with Bob Krasnow in 1968.

Blue Thumb Records assembled an eclectic roster of musical talent, also including Ben Sidran, Gerry Rafferty, The Credibility Gap, The Crusaders, Hugh Masekela, Ike & Tina Turner, the Pointer Sisters, Dave Mason, Gabor Szabo, João Donato, The Jazz Crusaders, Southwind, Mark-Almond, Nick DeCaro, comedy troupe National Lampoon, and Dan Hicks and His Hot Licks.

[6] In 1974, LiPuma took on a production assignment for Columbia Records (as Blue Thumb's co-owner, he could freelance at will), working with Barbra Streisand to create an album featuring the theme song to the film The Way We Were.

Further chart success continued with music by Michael Franks, Al Jarreau, Stuff, Eumir Deodato, Bill Evans, Antônio Carlos Jobim, João Gilberto and Dan Hicks.

From 1978–79, LiPuma was hired to handle Horizon Records, an imprint of A&M, where he worked with Brenda Russell, the Yellow Magic Orchestra, Seawind, Dr. John and Neil Larsen.

He revived the career of Little Jimmy Scott at Sire Records and produced the soundtrack for David Mamet's film Glengarry Glen Ross.

At the beginning of his tenure he met singer and pianist Diana Krall, eventually leading to long history of successful collaborative efforts amounting to around a dozen albums.

[4] Works from his collection, featuring pieces from artists Marsden Hartley, John Marin, Arthur Dove and Alfred Maurer, have been exhibited at various galleries and museums throughout the United States.