[4][5] Tremble was selected by the Carolina Panthers in the third round with the 83rd overall pick in the 2021 NFL Draft.

[8] Tremble signed his four-year rookie contract with Carolina on July 22, 2021.

[9] In Week 5, against the Philadelphia Eagles, he recorded his first NFL touchdown on a five-yard reception.

[11] On October 22, 2022, during Week 7 against the Tampa Bay Buccaneers, Tremble scored his first touchdown of the season on his only catch of the game on a 29–yard pass from P. J.

[15] His father, Greg Tremble, played in the NFL and was a member of the Dallas Cowboys who won Super Bowl XXX.