A second television drama adaptation titled Tomodachi Game R4 aired on TV Asahi from July to September 2022.

Yūichi Katagiri was taught the value of friendship when he was young, and it is thanks to his group of four friends that he is able to enjoy high school life today.

When their class's school trip funds are stolen, the five are dragged into the mysterious Tomodachi Game as a result of someone's debt.

In June 2022, another television drama adaptation produced by TV Asahi, titled Tomodachi Game R4, was announced.

It was directed by Takurо̄ Oikawa, Hajime Takezono, and Toshiaki Kamada, with screenplays by Takuji Higuchi and Shinya Hokimoto, and Yoshinori Nakamura composing the music.