It centers on the relationship between a male otaku named Tibet and his yaoi-obsessed fujoshi girlfriend Yaoi whose obsession manifests as a small, green furry monster.

A shōjo manga re-imagining of the series entitled Tonari no 801-chan: Fujoshiteki Kōkō Seikatsu written and illustrated by Jin was serialized in Kodansha's Bessatsu Friend from November 28, 2007 to April 13, 2009.

A spin-off manga series written and illustrated by Jun Minamikata called 801-shiki Chūgakusei Nikki: Tonari no Hina-chan started serialization in Romance Tiara in April 2009.

[4] The green monster featured in Tonari no 801-chan has its origins in 801-chan (やおいちゃん, Yaoi-chan), the real-life mascot of the Misono Bridge 801 shopping center in northern Kyoto, Japan.

Tonari no 801-chan is narrated by Tibet (チベット, Chibetto), otherwise known as Tibe-kun (チベ君, Chibe-kun), a twenty-eight-year-old company employee and boyfriend to Yaoi, otherwise known as Yaoi-chan (801ちゃん).

A spin-off manga series entitled 801-shiki Chūgakusei Nikki: Tonari no Hina-chan (801式☆中学生日記～となりのひなちゃん～) written and illustrated by Jun Minamikata started serialization in Romance Tiara on April 11, 2009.

The film stars Sō Hirosawa as Yaoi, and Koji Seto as Tibet, and also features Kotaro Yanagi playing a role.

[4] However, a 90-second "opening anime" called Tonari no 801-chan R (となりの801ちゃんR) was produced by A-1 Pictures and directed by Yutaka Yamamoto; it was bundled with the fourth volume of the original web manga released on September 10, 2009.