He played in Major League Baseball (MLB) for the Cincinnati Reds and Los Angeles Dodgers.

After the season, he asked the coaches if they wanted him off the team due to his poor performance, but they told him they thought he could make progress.

[4] Converted into a relief pitcher for his senior season, Cingrani tied the school record with 12 saves.

[2][5] He began his professional career with the Billings Mustangs of the Rookie-level Pioneer League, pitching in their starting rotation.

[15] Cingrani was traded to the Los Angeles Dodgers on July 31, 2017, in exchange for outfielder Scott Van Slyke and minor league catcher Hendrik Clementina.

In the postseason, he made two appearances in each of the NLDS and NLCS, giving up no runs and allowing only a single and a hit by pitch.

[17] On May 4, 2018, against the San Diego Padres at Estadio de Béisbol Monterrey, Cingrani was one of four pitchers involved in a combined no-hitter as the Dodgers won 4–0.

[20] In June 2019, Cingrani underwent arthroscopic surgery to fix a left labrum tear and was ruled out for the season.

[21] On July 31, 2019, the Dodgers traded Cingrani and Jeffry Abreu to the St. Louis Cardinals in exchange for Jedd Gyorko, international cap space, and cash considerations.