He played in Major League Baseball (MLB) for the Cincinnati Reds, Brooklyn Dodgers, Boston Bees / Braves, New York Giants and Chicago White Sox between 1930 and 1945.

[1] A native of Long Island City, New York, Cuccinello threw and batted right-handed; he was listed as 5 feet 7 inches (1.70 m) tall, with a playing weight of 160 pounds (73 kg).

During the 1945 season, the 37-year-old Cuccinello hit .308 for the White Sox, and just missed winning the American League batting title, one point behind Snuffy Stirnweiss' .309.

Nevertheless, with the World War II manpower shortage ending and hundreds of big league players returning to the game from military service, he was released during the offseason.

After being out of baseball in 1946, Cuccinello managed the 1947 Tampa Smokers (named after the city's large cigar business) of the Florida International League, then he spent 1948 as a coach for the Indianapolis Indians of the Triple-A American Association.