[18] Gonzales served as a Department of Defense fellow in the office of Senator Marco Rubio and also worked as an assistant professor of political science at the University of Maryland.

[28] To secure Gonzales' victory over his primary challenger Brandon Herrera, several establishment-allied super PACs put more than $4 million in TV advertising.

[30] Gonzales voted against impeaching Trump after the events of January 6, 2021, saying that the nation needed to heal and that he looked forward to working with President Biden to do that.

He published a press release on November 6, 2021, saying, "Last night, I voted against the infrastructure bill as it will only lead to more spending for the Democrats and this flailing administration".

Gonzales later published a press release on his official government web site on January 24, 2022, attempting to take credit for the bill's $75 million investment in the San Antonio River Authorities West Side Creeks Ecosystem Restoration Project.

[33][34] On May 19, 2021, Gonzales was one of 35 Republicans to join all Democrats in voting to approve legislation to establish the January 6, 2021 commission meant to investigate the storming of the U.S.

"[37] This came after Gonzales voted in favor of three contentious foreign aid packages for Ukraine, Israel, and East Asia, all of which required bipartisan backing to move on.

[45][46] Gonzales has cited cybersecurity as "a top priority in Congress" and has supported increased funding for Texan infrastructure against acts of cyberterrorism or ransomware.

[48] Gonzales supported amending the 2021 National Defense Authorization Act to remove a proposed red flag law provision.

[50] Gonzales supports keeping Title 42 expulsion in place and, along with Senators John Cornyn and Ted Cruz, wrote to Department of Homeland Security Secretary Alejandro Mayorkas and Department of Health and Human Services Secretary Xavier Becerra arguing that the removal of Title 42 would encourage illegal immigration at the southern border.

In response to the repeal of the Remain in Mexico policy under Biden, Gonzales called for an increase in immigration judges to process asylum cases "in days, not years."

[61] The PACT ACT which expanded VA benefits to veterans exposed to toxic chemicals during their military service, received a "nay" from Gonzales.