He served as head coach of the United States men's national ice hockey team at the 2018 Winter Olympics.

In what Rangers at the time called "the biggest [deal] in club history", Granato was traded with teammate Tomas Sandström to the Los Angeles Kings on January 20, 1990, in exchange for center Bernie Nicholls.

[2] Granato continued to be a prolific goal scorer with the Kings and was a key player in their run to the 1993 Stanley Cup Finals, contributing 17 points over the course of the playoffs.

On January 25, 1996, Granato suffered a serious head injury in a game against the Hartford Whalers that resulted in a bleeding on the left lobe of his brain.

[5] He underwent surgery and although there was speculation he would not play again, he returned to the ice in the 1996–97 NHL season after being traded to the San Jose Sharks.

After a sub-par start to the season, the Avalanche fired head coach Bob Hartley on December 18, 2002, and Granato was subsequently promoted to replace him.

Granato guided the Penguin's defense (2.49 goals against per game, tenth) and penalty killing (85.0 percent, fifth) to top-ten league finishes during the 2013–14 NHL season.

Siblings Don, Rob, and Cammi were influenced by the Chicago Blackhawks and the 1980 Winter Olympics USA gold medal.

[22] On December 11, 2023, Granato announced that he had been diagnosed with Non-Hodgkin lymphoma, and that he would be taking a leave of absence from his television career to begin treatment on the cancer that same week.