[3] Harrison made his professional debut on July 2, 2011, scoring a first-round technical knockout (TKO) over Uwe Tritschler at the Imtech-Arena in Hamburg, Germany.
After compiling a record of 24–1 with 20 knockouts (KO) – his only defeat coming against Willie Nelson via ninth-round TKO in June 2015 – Harrison faced Jarrett Hurd (19-0, 13 KOs) on February 25, 2017, at the Legacy Arena in Birmingham, Alabama, with the bout being televised on Premier Boxing Champions (PBC) on FOX.
[4][5] The rematch was a highly competitive bout, in which Charlo managed to regain the WBC light middleweight title.
In the eleventh round, Charlo dropped Harrison twice and had him stuck on the ropes when the referee decided to end the fight.
[7] On the 22nd January 2023 it was announced Tony Harrison will be taking on Tim Tszyu for the interim WBO junior middleweight title on March 12 in Australia.