[5] Humphries began DJing at college and got his first professional gig in 1981 at the then-new New York station 98.7 Kiss-FM following a chance encounter with Shep Pettibone.

"[10] Humphries's earliest UK appearances were at club nights in London, such as Danny Rampling's Shoom and Norman Jay's High On Hope at Dingwalls.

[11] In the 1990s, as dance music grew in popularity in the UK and throughout Europe, Humphries was given a residency at the London superclub Ministry of Sound.

Humphries has a large back catalogue of studio production work; remixes spanning a broad number of styles from artists make up the bulk of this output.

These include his work for Ministry of Sound, London's Fabric,[13] Strictly Rhythm, DMC, and, returning to his roots, his Zanzibar Classics compilations.

[18] MK, whose remix of “Push the Feeling On” by the Nightcrawlers reached #3 in the UK charts in 1995, also cites Humphries as a major influence.