The fourth African American general manager in MLB history,[a] he was promoted to GM of the franchise on October 16, 2007, having previously held the position of director of player development since 2002.

Reagins pledged to the Theta Upsilon chapter of Phi Beta Sigma fraternity in 1988, while attending California State University, Fullerton.

He is a member of the Buck O'Neil Scout Association and an active supporter of Major League Baseball's Urban Youth Academy.

The Angels' farm system posted winning records in four of the six seasons (2003-05-06-07) and was named "Minor League Organization of the Year" in 2003 by The Sporting News.

It produced players such as Howie Kendrick, Reggie Willits, Robb Quinlan, Kendry Morales, Erick Aybar, Jeff Mathis, Mike Napoli, Jered Weaver and Joe Saunders – all of whom made significant impacts on the 2007 American League West Division champion team.

A little more than a month after taking over for Bill Stoneman as GM, Reagins traded Gold Glove shortstop Orlando Cabrera to the Chicago White Sox for starting pitcher Jon Garland.

While many point to the Angels not making the playoffs in consecutive years since 2000–01 as the reason, others identified his trade of Mike Napoli and Juan Rivera for Wells being a significant factor.