Luis Antonio Rodríguez (born August 15, 1970 in Río Piedras, Puerto Rico) is a former Major League Baseball (MLB) shortstop and manager.

Rodríguez also played in the Red Sox, Mariners and Cubs minor league systems from 1992 to 2001, hitting .243 with 11 home runs and 167 RBI in 616 games.

On May 16, 2018, Rodríguez was contracted by the Puerto Rico Islanders of the Empire Professional Baseball League (EPBL).

On August 12, 2018, Rodríguez managed the Islanders to the Zakari Cup (EPBL) championship by besting the New York Bucks in the final series.

In January 2022, Rodríguez was hired by the Tigres de Quintana Roo of the Mexican League as the team's manager.