After his football career, he worked as a sideline analyst for NFL games broadcast on the Fox Network from 2003 to 2015.

He also hosted various shows on television, such as the home renovation program Man Caves on the DIY Network.

He was a starting defensive tackle in his sophomore and junior seasons (1986 and 1987) under head coach Mike Gottfried.

[5][6][7] During a practice in April 1988, Siragusa tore his left anterior cruciate ligament, and underwent surgery that forced him to sit out the entire 1988 season.

[13] In the 1991 season, he started in 6 of his 13 game appearances and recorded 2 sacks, 1 fumble recovery, and 46 combined tackles.

[17] In the 1995 season, he appeared in and started 14 games and recorded 2 sacks, 49 total tackles, and 1 forced fumble.

[19] Siragusa was open about his dislike for new coach Lindy Infante and the team's Vice President of Football Operations Bill Tobin.

[26] He was a part of the 2000 Baltimore Ravens defense that allowed the fewest total points in NFL history for a 16-game season.

[42] On June 22, 2022, Siragusa died in his sleep at his home in the Ortley Beach of Toms River, New Jersey, at the age of 55.