He played in Major League Baseball (MLB) for the Colorado Rockies, Chicago Cubs, and Los Angeles Dodgers.

[1] He signed with Cleveland, forgoing his commitment to play college baseball at the University of San Diego.

During his first major league start on April 10, 2016, Wolters got his first career hit when he singled against James Shields.

Wolters hit his first career home run on June 25, 2016, against Shelby Miller of the Arizona Diamondbacks in the bottom of the 6th inning, scoring Brandon Barnes.

[9] He went 2–4, scoring the two final runs to take the lead, one in the seventh off an error, and one in the ninth of a double from Alexi Amarista.

Wolters established career highs offensively in batting average (.262), games played (121) and RBIs (42) in 2019.

[citation needed] On February 11, 2021, Wolters signed a minor league contract with the Pittsburgh Pirates organization that included an invitation to Spring Training.

[13] On April 14, 2021, Wolters was designated for assignment after Austin Romine was activated off of the injured list.

[14] On April 26, Wolters was again selected to the active roster when Romine was placed on the injured list with a left wrist sprain.