She has appeared on several television series in guest roles, including Sex and the City,[1] Monk, Third Watch, Curb Your Enthusiasm and Elementary.

[7] She received a Screen Actors Guild Award nomination for Outstanding Performance by an Ensemble in a Comedy Series alongside her Weeds co-stars in 2006.

[8] Two years later, Patano earned an NAACP Image Award nomination for Outstanding Supporting Actress in a Comedy Series as Heylia.

[12] Patano portrayed Nurse O'Neil in a 1997 production of The Sunshine Boys at the George Street Playhouse.

[16] Her performance in this production received positive reception, with one critic calling her "delightful" and "magnetic.