Topchikhinsky District (Russian: Топчи́хинский райо́н) is an administrative[1] and municipal[4] district (raion), one of the fifty-nine in Altai Krai, Russia.

It is located in the center of the krai.

The area of the district is 3,300 square kilometers (1,300 sq mi).

[2] Its administrative center is the rural locality (a selo) of Topchikha.

[3] Lake Peschanoye is located in the district.