Accompanying him are his best friend Zoe, a little girl who helps to make things right, his buddy Bike Bob, who he rides with in the city of Townville, and the G-Team (Mole, Pigeon, Bunny Twins, Turtle, and Toad) — which is a pair of cute critters who only Gigio can understand — who he can call upon using his Gigio Watch.

Together, they make it their mission to solve any problem in the city of Townville, travelling with the help of the G-Bus that Bob built.

[1] Topo Gigio is an animated adaptation of the character of the same name that was created by Italian artist Maria Perego, and her husband Federico Caldura, in 1958.

Early promotional material reveal that the show was originally titled "Topo Gigio: The New Animated Series".

[7] The original English version was first broadcast on Canal Panda's Spanish feed, on its English-language audio track,[8] on July 1, 2021.