Topusko is an underdeveloped municipality which is statistically classified as the First Category Area of Special State Concern by the Government of Croatia.

Through the millennia, the Illyrians, the Celts, and most of all, the Romans testified to their existence and their fascination with this area of impulsive vivacity, and they made a statio, called Ad Fines.

The remnants of the luxurious architecture, the devices for heating the houses with hot water, the painted walls of the houses, the discovered altars dedicated to the Roman and domestic divinities, the grave-monuments, tools, ornaments, money (which was thrown into the thermal springs) are very valuable artifacts that tell us about the persistence of the colony through the whole antiquity.

King Andrew II goes to the holy war to Jerusalem at the beginning of the 13th century, and makes a vow that in case he comes back he will build a monastery and an abbey in Topusko, in token of gratitude.

Colonel Nestor started the development of Topusko, but the turning point was the arrival of the king Francis II in 1818, and the repeated donation of money for the construction.

During World War II, the town was occupied by Axis troops and was included into the Pavelić's Independent State of Croatia (NDH).

The NDH forces killed in a cruel way more than 600 Serbs in Staro Selo Topusko, while and the largest massacre occurred between 28 July and 3 August 1941 when 250 villagers were executed.