The outbreak was responsible for ten tornado-related fatalities on April 24, all in Mississippi from a single supercell that crossed the entire state.

A complex weather system began to track across the central and southern United States beginning on April 22.

A tornadic storm in Kearny County uprooted trees and caused power outages at residences west of Lakin.

Grain bins near Scott City were damaged, a barn partially collapsed with part of its roof torn off and some trees and power lines were reported down from it.

Moist air ahead of the cold front in the south central states allowed for strong to severe thunderstorms to develop across the Mississippi Valley.

[12] On April 24, an energetic upper level storm system strengthened as it moved from Texas to the southern Great Lakes Region.

This set the stage for a significant severe weather outbreak with the potential for strong and violent tornadoes, large hail, and damaging winds.

[13] As a result, the Storm Prediction Center issued a rare high risk of severe weather for portions of Mississippi, Alabama, Tennessee, and Kentucky, the first such issuance since April 26, 2009.

[14] Four "particularly dangerous situation" tornado watches were issued that day for areas of Missouri, Kentucky, Illinois, Arkansas, Louisiana, Mississippi, Tennessee, and Alabama.

The storm left the downtown area of Albertville in complete destruction, then downed trees and power lines in DeKalb County.

[30] An EF2 tornado that moved over Jasper and Lauderdale counties caused significant structural damage to a church and destroyed an outbuilding.

It crossed the Mississippi River shortly thereafter, and damaged or destroyed numerous homes on the north side of Eagle Lake.

The tornado then moved across the Delta National Forest in Issaquena and Sharkey Counties, causing major tree damage.

As the tornado approached the intersection of US 49 and MS 16 on the south side of Yazoo City, it reached its widest point and maximum intensity.

The tornado continued moving through residential areas on the southeast side of Yazoo City, heavily damaging or demolishing numerous homes.

As the tornado approached the area just south of Durant and crossed US 51, it narrowed and reached one of its weaker points in its track, but was still on the ground.

The tornado intensified further as it crossed the Natchez Trace Parkway, and once again produced high-end EF3 damage as it passed northwest of Weir.

The tornado rapidly narrowed and weakened as it crossed into Oktibbeha County, and dissipated north of the town of Sturgis after being on the ground for nearly three hours.