Severe and tornadic activity continued into the next day as the system moved eastward with numerous tornadoes reported in Mississippi and Alabama.

On the evening of March 22, a supercell moved through the New Orleans metropolitan area, with an EF3 tornado producing severe damage in Arabi, resulting in one death and at least two injuries.

On March 19, 2022, the Storm Prediction Center (SPC) issued a Day 3 enhanced risk for the areas encompassing central and eastern Texas and western Louisiana, as readings indicated that atmospheric conditions would become supportive for a damaging severe weather outbreak.

A powerful supercell developed just outside the main risk area, producing a strong, long-tracked EF3 tornado, that caused considerable damage in the town of Jacksboro, Texas.

At dawn on March 22, the Storm Prediction Center issued a moderate risk encompassing central Louisiana and western Mississippi, and a large 15% hatched probability for tornadoes was introduced, as multiple sustained supercells were expected to develop in the area.

An intense high-end EF3 tornado caused considerable damage in the eastern New Orleans neighborhoods, as it was widely captured on video from multiple angles.

The line of storms that had moved through the Gulf Coast the previous night produced isolated wind damage and a weak tornado in the Florida Panhandle and Georgia.

Farther north in the Ohio Valley, multiple severe thunderstorms, including supercells, formed at moved northeastward, producing scattered wind damage and hail.

The most significant area of tornadoes occurred when a small cluster of supercells formed of the higher terrain in the Western Carolinas that evening.

An isolated severe threat was expected the next day across most of the southeastern coast, but no reports came in, as the storm system exited completely into the Atlantic.

[16] On March 22, a strong tornado touched down and moved through the New Orleans metropolitan area, originating in Gretna in Jefferson Parish at 7:21 p.m. CDT (00:21 UTC).

After crossing the river, the tornado intensified to EF2 strength as it moved into St. Bernard Parish and the community of Arabi, just east of the Lower Ninth Ward of New Orleans.

The tornado was broadcast live on television by skycam on WDSU as it was passing through the area, exhibiting horizontal vortices and accompanied by power flashes.

[120] Moving almost due-north through the middle of Arabi, the tornado caused a relatively narrow path of severe damage along the Friscoville Avenue corridor.

Many homes in this area were badly damaged and sustained total loss of their roofs, detached garages were destroyed, power lines were downed, and trees were snapped.

The exterior wall of an automotive repair business was blown outward, and a metal warehouse building that housed a brewery was destroyed.

The tornado momentarily weakened back to EF2 strength within the vicinity of Sidney Street, and dozens of homes suffered partial to total roof loss along this segment of the path.

A couple of poorly anchored homes built on raised pier foundations were swept completely away, and debris was scattered throughout the neighborhood.

Some metal truss electrical transmission towers were significantly damaged along the bank of the Florida Canal as the tornado exited Arabi.

The tornado weakened substantially as it moved back into Orleans Parish across Bayou Bienvenue and the Gulf Intracoastal Waterway, again causing minor damage consistent with an EF0 rating.

Several fences, trees, and tree limbs were downed, and more homes sustained mainly minor roof, siding, and garage door damage in the area of Read Boulevard, Chef Menteur Highway (US 90), Prentiss Avenue, and Coronado Drive before the tornado dissipated at 7:38 p.m. CDT (00:38 UTC) near Dwyer Road at Joe W. Brown Memorial Park, south of I-10.

[3] Due to the projected path of severe weather, many schools either closed early or cancelled after-school activities March 22 in Louisiana and Mississippi to allow for students to get to safety and shelters were opened for those without adequate protection.

[137] Louisiana governor John Bel Edwards issued a state of emergency for Jefferson, Orleans, St. Bernard, and St. Tammany parishes following the tornadoes.