A long-lived tornado outbreak sequence affected the Southern Plains, the southeastern and Middle Atlantic region of the United States from May 7–11, 2008.

The event occurred less than a week after a deadly tornado outbreak that principally affected the state of Arkansas and killed 7 people.

KOCO-TV recorded a 124 miles per hour (200 km/h) wind gust while Chief Meteorologist Rick Mitchell was reporting on the storm.

One particular tornado was caught on tape by a security camera at a business near Leighton in Colbert County which overturned cars at a parking lot.

Two FedEx planes at the Piedmont Triad International Airport were pitched off the tarmac as the storm lifted near the area.

[11] A moderate risk of severe storms was issued for a large portions of the Mississippi Valley as well as the Eastern Plains.

Severe storms began to occur across northwestern Arkansas, southeastern Kansas and eastern Oklahoma during the late afternoon hours.

Two people were killed in Laurens County, Georgia, and at least 85,000 customers were left without power in the Atlanta metropolitan area.

[16] A violent EF4 tornado was also confirmed near Darien in McIntosh County where numerous buildings near Interstate 95 were heavily damaged or destroyed.

[18] In addition to the tornado fatalities, one person was killed due to straight line winds in Barrow County, Georgia.

Twenty blocks of the town suffered extensive damage with houses and businesses destroyed or flattened, and some swept away.

[20] Most of the fatalities in Missouri were reported near the Racine community at the intersection of Route 43 and Iris Road, northwest of Neosho, where automobiles were thrown as far as 1⁄2 mile (800 m) away.