In 1911, the T H and B was the first railway in North America to install the Absolute Permissive Block Signalling for single operation track allowing safe and efficient travel avoiding head-on and rear end collisions by holding one train back on the siding.

In 1977, CP Rail acquired the NYC's portion (then part of Conrail), giving the CPR 90% ownership.

Increased operating costs and tighter profit margins in that decade meant the future of the railroad was much in doubt.

Trains now use the former NYC CASO Subdivision from Welland west to the former junction with the TH&B at E & O (Erie & Ontario) Tower, where a new connecting track was constructed to access the remainder of the line to Port Maitland via Dunnville.

With up to 26 daily trains blocking growing automobile traffic along Hunter Street, the TH&B eventually elevated the tracks above the surrounding land and thus needed to replace the original Hamilton station.

In 2019, despite objections by the building's owner, a property developer, City Council approved a historical designation for the oldest portions of the former railway station.

[6] The TH&B's Jerseyville station is now at the Westfield Heritage Village, near Rockton, Ontario, alongside preserved TH&B steam locomotive #103, which was moved to this site in 1977 after being on display in Gage Park since 1956.

[7] Perce Hankinson, who began his railway career in 1917 with the Michigan Central Railroad (MCR), realized a lifelong dream when made Vice-President and General Manager of the TH&B on June 7, 1965.

Starting in January 1948, the railway purchased four NW2 diesel switchers from General Motors Electro-Motive Division.

That completed the railway's diesel fleet, and the TH&B did not purchase any new motive power for the remainder of its operating years.

In his song "Under a Stormy Sky" (from the 1989 album Acadie), the Quebec-born singer, songwriter, and producer Daniel Lanois pays homage to the presence of TH&B locomotives during his youth: "I hear the T.H.& B. the diesel turning, calling you and me to the city of steel, smokestack - spinning wheel come with me Bebette, oui under the stormy sky"