"[4] The show features several clips from various vintage footage, one of which is a rap duo Riff Raff, who perform a song "D-I-S-E-A-S-E", which is about practicing safety against the contraction of AIDS in front of their classroom as part of an assignment, from a 1987 educational film.

Derrick is shown holding a lit cigarette, despite his opposition in real life as part of the Truth.com campaign, and in show as he attempts to dissuade a teenage boy against smoking.

Host Derrick appears in front of an audience of children, and begins by announcing what will precede over the course of the recording, which includes a performance by Good Charlotte.

It features a skit with the 1991 Miss Teenage North America Pageant contestants, who act out buying and using drugs in an effort to inform the teens of potential death by "drugacide".

Totally for Teens was released on DVD as part of Adult Swim in a Box on October 29, 2009,[9] on an extra DVD of Adult Swim pilots, along with Cheyenne Cinnamon and the Fantabulous Unicorn of Sugar Town Candy Fudge, Korgoth of Barbaria, Welcome to Eltingville, and the pilot episode of Perfect Hair Forever.