[2] Scott Caan, Daniel Dae Kim, Chris O'Donnell, and LL Cool J appeared in both parts of the event as Danny Williams, Chin Ho Kelly, G. Callen, and Sam Hanna, respectively.

When Hawaii Five-0 Task Force members Detective-Lieutenant Chin Ho Kelly, Detective-Sergeant Danny "Danno" Williams, and Officer Kono Kalakaua arrive, they are updated on the case and told that the man dropped dead of smallpox.

Danny finds out that Dracul is on the watchlist of the Naval Criminal Investigative Service Office of Special Projects division in Los Angeles.

Kono deducts that Dracul was crossed by his partner Doctor Jarrod Prodeman, and finds that he bought a ticket to Los Angeles.

As the plane begins to land in Los Angeles flight attendants grow suspicious when a passenger has not exited the bathroom.

NCIS Special Agents Kensi Blye and LAPD-NCIS Liaison Officer Detective Marty Deeks head to the airport and begin looking for Prodeman.

[8] Initially Chris O'Donnell and LL Cool J were set to appear in Hawaii Five-0 while Alex O'Loughlin and Scott Caan were set to appear in NCIS: Los Angeles[9][10] However, on March 2, 2012, prior to the crossover's filming CBS announced that O'Loughlin would miss shooting some episodes of Hawaii Five-0 to seek drug treatment related to pain management medication prescribed after a shoulder injury.

[15] During filming NCIS L.A. creator stated "Crossovers are not easy to pull off when you're working in the same town, and when you've got the other show being shot a five-hour flight away, it's particularly challenging.

"[16] Jim Garner with TV Fanatic who reviewed the first part of the crossover said "it was a lot of fun having Hanna and Callen from NCIS: Los Angeles visit the Five-0" and gave the episode an editorial rating of 4.4 out of 5 stars.

[17] Carla Day also with TV Fanatic who reviewed the second part said ""Touch of Death" worked well, but the crossover was a bit of a mess.

Back in Hawaii, it was all about Comescu, but then it took an odd shift from Jarrod Prodeman selling to Dr. Holden in Los Angeles" and gave the episode an editorial rating of 4.6 out of 5 stars.