The railway from Toulouse to Bayonne is an important French 319-kilometre long railway line, that connects the southern city Toulouse to the southwestern town Bayonne, running along the foothills of the Pyrenees.

At Lourdes it turns west again and starts following the Gave de Pau downstream, on its right bank.

At Saint-Pé-de-Bigorre the river and the railway turn northwest towards Pau and Puyoô.

The Gaves réunis is crossed at Hastingues, and the railway continues downstream along the left bank of the river Adour until it reaches Bayonne, its western terminus.

Finally in 1867 the missing sections from Montréjeau to Tarbes and from Lourdes to Pau were opened.