It is not known if members of the historic Osage people, who dominated a large area of present-day Missouri at the beginning of the 19th century, ever occupied the site.

[7][8] The site was acquired by the Missouri state park system in 1967[4] and added to the National Register of Historic Places in 1969 as NRIS number 69000113.

[1] The earliest portion of Towosahgy State Historic Site is in the southern half, where a Late Woodland period village once stood.

[6] Later the site was fortified and built up as a Mississippian village with seven platform mounds, most surrounding a central plaza area.

Punctuated, incised, fabric impressed, and red, black, and brown painted/slipped sherds, typical decorating methods, are all present.