With Kasımpaşa, he became the highest scoring Egyptian player in the Turkish top flight in a single season which prompted the club to make the transfer permanent in 2018.

[8] After being promoted to the senior squad by manager Manuel José de Jesus, on the advice of Maher, he made his professional debut in the 2012 CAF Champions League as a substitute in place of Mohamed Aboutrika in a match against local rivals Zamalek.

[19] His arrival at the club was disrupted by a broken shoulder sustained while training with his national team in the United Arab Emirates,[20] ruling him out for several months after being forced to undergo surgery.

[21] Anderlecht manager Besnik Hasi stated his disappointment in the disruption of the loan spell and admitted that it had been difficult for the club to analyse Trézéguet's ability.

[28] In March 2016, Anderlecht announced they were considering exercising their option to sign Trézéguet permanently from Al Ahly for a reported transfer fee of €2.2 million,[29] despite only making seven league appearances in his first season.

[34] In his first seven appearances for the club, he was directly involved in five goals, scoring two and assisting three including a solo effort against Gent after starting a run from inside his own half,[35] leading manager Glen De Boeck to label him the "most talented player in our team.

"[38] In the final match of the season, Trézéguet scored the opening goal of a 2–0 victory over KV Kortrijk that saw Mouscron overtake Westerlo to avoid relegation from the Belgian First Division A.

[43][44] He eventually joined Turkish side Kasımpaşa on a season-long loan deal with the club having the option to make the move permanent for €2 million.

He held talks with representatives of fellow Turkish side Galatasaray while attending a national team training camp in Italy,[53] later describing the club as his preferred destination.

The deal was to include spending the first year on loan with fellow Serie A side Parma due to Milan already reaching their foreign player quota for the upcoming season.

[59] On 24 July 2019, Trézéguet joined Premier League club Aston Villa for a fee of £8.75 million,[60] subject to work visa and international clearance.

[65] On 28 January 2020, he scored an injury time winner in an EFL Cup semi-final against Leicester City, to send Villa to their first final in the tournament since 2010.

[66] Trezeguet played a key role in Aston Villa's strong run of form in their final 4 games of the season, scoring 3 crucial goals against Crystal Palace and Arsenal to help them achieve Premier League survival.

[71] He returned to the first team on 2 January 2022, in a 2–1 away defeat to Brentford, in which he received criticism for appearing to simulate contact with Saman Ghoddos in order to try and win a penalty.

[74] On 4 July 2022, Trézéguet returned to the Süper Lig once again, joining reigning champions Trabzonspor on a permanent deal,[75] for a transfer fee rumoured to be around £4.25M.

[81] Trézéguet returned from injury in time to be selected by Carlos Queiroz for the squad to play in the 2021 Africa Cup of Nations - which was taking place in January 2022, due to COVID-19.