Tröger's base and its analogs are soluble in various organic solvents and strong acidic aqueous solutions due to their protonation.

The inversion can be stopped by conformational strain as Tröger's base has demonstrated that nitrogen is capable of forming a stereogenic center in organic molecules.

[4] Prelog performed column chromatography using a chiral stationary phase as a relatively new method that later on gained popularity and became a standard procedure.

[11] Tröger's base is a diamine, which exceptionally exhibits chirality due to the prevented inversion of configuration of two bridgehead stereogenic tertiary amine groups.

Tröger's base and its analogs racemize under acidic conditions through the formation of iminium intermediates,[12] which can be prevented by the replacement of methano-bridge with an ethano-bridge.

Chromophore-carrying analogs of the Tröger's base[10][12] have displayed NLO properties[18] and can be used as molecular switches[11] and liquid crystal dopants.