The current/present day route was opened on June 2, 2017[1] connecting the Astrid Pre-metro station, Antwerp South and P+R Schoonselhof in Hoboken with Wijnegem.

From there it runs to Wijnegem Shopping Center, intersecting the R11 (Antwerp's Second Outer Ring), before making its way to Ruggeveld in Deurne.

On June 12, 1906, the tram route was extended from the Turnhoutsepoort to the Turnhoutsebaan in Deurne, a total extension of 5 km (3.1 mi).

During World War I, the tram route 10 was restricted to the Turnhoutsepoort to the Melkmarkt in Antwerp City Center.

In 1933, tram route 10[3][circular reference] ran between the Melkmarkt in the city center and the Schotensesteenweg in Deurne.

This route would run Tram 10 from Wijnegem to Deurne Village (Dorp) then overground to Antwerp Central Station and from there to Melkmarkt.

In February 2017, due to work on the bridge over Antwerp's Orbital Ring road (on the Turnhoutsebaan), Tram 10 was diverted and would no longer serve Deurne Village, instead it would serve Deurne South and the Herentalsebaan and therefore make use of the Premetro Network.

Since September 16, 2017, Tram route 10 has driven without diversion between Wijnegem and Hoboken P+R Schoonselhof via the new tunnel.