[1] Trans Safety Network was launched in October 2020, in response to what it saw as an increase in anti-transgender campaigns and political lobbying in the United Kingdom.

[4] In November 2021, TSN was incorporated as a Community Interest Company (CIC), whose founding Directors were Shash Appan and Nichola Phoebe Queen.

[5] On 24 June 2023, the group's director, Jess O'Thomson was assaulted and injured while reporting for TSN by far-right demonstrators organised by Turning Point UK at a Drag Queen Story Hour event in Lewisham, with another activist left bloodied.

In February 2022, TSN was a co-signatory to an open letter calling for a review of the EHRC by the United Nations Human Rights Council (UNHRC) and Global Alliance of National Human Rights Institutions (GANHRI), consignees included: Stonewall, Liberty, the Good Law Project, Mermaids and LGBT Youth Scotland.

[11] In 2023, O'Thomson, met Victor Madrigal-Borloz, the UN independent expert on sexual orientation and gender identity, who was preparing a report on LGBTQ rights in the UK.