Grover's disease (GD) is a polymorphic, pruritic, papulovesicular dermatosis characterized histologically by acantholysis[2]: 529  with or without dyskeratosis.

It is characterized by papules and papulovesicles with excoriations occurring on the chest, back, lower sternum, arms, and thighs.

Suspected triggers of disease activity include heat and sweating, sunlight, and adverse reaction to medications[5]: 24  as well as ionizing radiation, end-stage renal disease/hemodialysis, and mechanical irritation or prolonged bed rest.

[8] Finally, smaller series have detailed an association with pyoderma gangrenosum, bacterial and viral infections, and occasionally, malignancies.

[13] Grover's disease affects chiefly white adults in the fifth decade or later, and appears to be around 1.6 to 2.1 times more common in men than in women.

[citation needed][9] This condition was first reported in 1975 by the American dermatopathologist, Ralph Wier Grover (1920–2008) while working at Franklin Hospital in New York.