The Transportation Building is a 44-story skyscraper at 225 Broadway on the corner of Barclay Street in the Civic Center neighborhood of Lower Manhattan in New York City.

It was built in 1927 and was designed by the architecture firm of York & Sawyer, in the Renaissance Revival style,[1] using setbacks common to skyscrapers built after the adoption of the 1916 Zoning Resolution.

The site of the Transportation Building had previously been the northern portion of the Astor House luxury hotel.

In 1913, the southern part was razed and replaced in 1915-16 with the Astor House Building at 217 Broadway, which is still extant.

The northern part was torn down in 1926 to make way for the Transportation Building.